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ザクロ抽出発酵物(ウロリッチ®)摂取による血管内皮機能改善効果と安全性の検証―プラセボ対照ランダム化二重盲検並行群間比較試験―
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JPY
Abstract
Objectives Urolithin A, an intestinal metabolite of ellagic acid contained in nuts, pomegranate and berries is a component that has been reported to have an autophagy/enhancing effect and is attracting attention. In this study, a double-blind, parallel-group comparative study was conducted to investigate the effects and safety of ingestion of fermented pomegranate extract(containing 10% urolithin A) on vascular endothelial function. Methods We conducted a placebo/controlled, randomized, double-blind, parallel-group study using 36 patients with impaired vascular endothelial function. They were divided to 3 groups, high dose group(50 mg/day of urolithin A), low dose group(10 mg/day)and placebo group for 12 weeks. Vascular endothelial function was evaluated by measuring flow-mediated dilation(FMD). In addition, a blood test was conducted to examine safety. Results The low dose group showed a tendency to improve vascular endothelial function 8 weeks after ingestion(P=0.078). In addition, no safety problems were observed with the intake of supplement containing urolithin A for 12 weeks. Conclusion These results suggested that ingestion of urolithin A 10 mg╱day is expected to improve vascular endothelial function and that it is safe after 12 weeks of ingestion. (UMIN-CTR ID: UMIN000042014)
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