薬理と治療

Abstract

Objective　Dyslipidemia includes hyper-low-density lipoprotein（LDL） cholesterolemia, hypo-high-density lipoprotein（HDL）cholesterolemia, hypertriglyceridemia, and hyper-non-HDL cholesterolemia. Hyper-LDL cholesterolemia is one of the most important risk factors for arteriosclerotic diseases; thus, it is important to control serum LDL cholesterol levels. For patients with hyper-LDL cholesterolemia, treatment with pharmaceuticals including statins, also known as 3-hydroxy-3-methylglutaryl coenzyme A（HMG-CoA）reductase inhibitors, is effective. On the other hand, diet improvements are recommended for borderline or mild LDL cholesterolemia prior to medical interventions, a promising method is taking functional foods such as polyphenols derived from fruits and vegetables. Herein, we conducted a randomized, double-blind, placebo-controlled, parallel-group comparison trial to investigate the effects of kaki-tannin on reducing serum LDL cholesterol levels. Methods　Sixty subjects with borderline or mild hyper-LDL cholesterolemia were randomly assigned to either a group that received test food containing 2.1 g of kaki-tannin or a group that was administered placebo for a 12-week intake period. Blood analysis was performed at 0, 4, 8, and 12 weeks. Serum LDL cholesterol levels were the primary outcome, and serum HDL cholesterol, total cholesterol, non-HDL cholesterol, and triglyceride levels were the secondary outcomes. Results　Serum LDL cholesterol levels at 4, 8, and 12 weeks and non-HDL cholesterol levels at 4 and 8 weeks were significantly lower in the test food group than in the placebo group. Conclusion　Kaki-tannin reduced serum LDL cholesterol levels, and was a useful functional food for controlling LDL cholesterol levels in borderline and mild hyper-LDL cholesterolemia. Moreover, kaki-tannin reduced serum non-HDL cholesterol levels. This suggests that kaki-tannin had an effect on the lipoproteins that induce arteriosclerosis such as remnant lipoprotein cholesterol and small dense LDL cholesterol（. UMIN ID: UMIN000044129）