薬理と治療

Abstract

Objectives　This randomized, double-blinded, placebo-controlled, parallel-group study aimed to evaluate the effect of Lagerstroemia speciosa leaf extract and exercise on gait function, posture, and quality of life（QOL）. Methods　Forty participants were included in this study and were randomly assigned into two groups: the test food group and placebo group. The participants consumed either food containing L. speciosa leaf extract （test; 2.2 mg╱day as corosolic acid）or food not containing corosolic acid（placebo）for 8 weeks. The participants were also instructed to exercise 4-5 times a week, during the study period, and the exercise load was gradually increased. Primary（gait function） and secondary（posture assessment using X-rays and questionnaire using SF-36 and visual analogue scale （VAS））outcomes were evaluated before, and after 4 and 8 weeks following food administration. Results　The test food group showed significant improvements in gait speed, timed up and go test, lumbar lordosis angle, physical component summary in SF-36, and VAS（P＜0.05）than the placebo food group. During the study period, no adverse events were attributed to the test foods. Conclusions　Overall, the findings indicated that L. speciosa leaf extract and the exercise can improve gait function, posture, body-related concerns, and QOL in adult men and women. （UMIN-CTR ID: UMIN000043824）