薬理と治療

Abstract

Background　Tongkat Ali has been used in medical treatments in South-East Asian countries and the health benefits with their products consumption have been well reported, but few studies have reported the effect of Tongkat Ali supplementation on stress markers and sleep quality. Objectives　The aim of the present study was to assess the efficacy of the intake of Tongkat Ali supplement, compared with the placebo, over a 4-week period, on stress markers and sleep quality, using the Profile of Mood States（POMS）and Oguri-Shirakawa-Azumi sleep inventory MA version（OSA-MA）. Methods　We conducted a clinical parallel, double-blind, placebo-controlled trial study to assess the efficacy of the Tongkat Ali supplement on stress markers and sleep quality. 33 healthy adults aged 30 to 60 years were divided by age and body mass index（BMI）at baseline, into the Tongkat Ali group, in which the participants consumed the Tongkat Ali supplements, and the placebo group, in which the participants consumed placebo tablets. Results　At week 4, improvements in the score from baseline（week 0）in vigour（VA）and Friendliness of POMS were observed only in the Tongkat Ali group（P＜0.01, P＝0.03, respectively）. A significant improvement in the score between 0 week to 4 weeks in sleepiness on rising using OSA-MA was also observed only in the Tongkat Ali group（P＜0.01）. Conclusions　The study indicated the intake of Tongkat Ali supplements has the potential to improve stress markers and consequently improve the sleep quality in healthy Japanese adults. （UMIN000044295）（Jpn Pharmacol Ther 2022；50：871‒6）