薬理と治療

Abstract

Objectives　The purpose of this study was to verify that the food consisting of rice bran fermented product containing 3-（4-hydroxy-3-methoxyphenyl）propionic acid（HMPA）has theeffect of reducing visceral abdominal fat in healthy adults. Methods　A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 90 healthy volunteers（Aged 20-64, BMI 23 or more and less than 30）. Subjects were randomly assigned to receive either test food or placebo. Daily intake of the test food for 12 weeks. Subjects were assessed on abdominal fat area, physical measurement, and safety assessment. Abdominal visceral fat area was the primary outcome, and physical measurements, abdominal subcutaneous and total fat area, and blood parameters were the secondary outcomes. Results　Abdominal visceral fat area at 12 weeks was significantly lower in the test food group than in the placebo food group. Moreover, waist circumferences at 8 and 12 weeks were significantly lower in the test food group than in the placebo food group. Conclusion　The food consisting of rice bran fermented product containing HMPA reduced abdominal visceral fat area and waist circumference. This study findings indicate that the food consisting of rice bran ferment containing HMPA have an effect of reducing abdominal visceral fat in healthy men and is useful functional food for controlling visceral fat（. UMIN-CTR ID: UMIN000044727）（Jpn Pharmacol Ther 2022；50：1031‒40）