薬理と治療

Abstract

Objectives　The aim of this study was to evaluate the effects of combined oral supplements of sesame lignans and astaxanthin on feeling of daily fatigue. Methods　A ramdomized, double-blind, placebo-controlled, parallel-group comparison study was conducted with subjects feeling fatigue with aging and on daily. Two hundred seventy-two Japanese volunteers were randomly assigned to 2 groups and ingested either placebo or the test foods containing 10 mg sesame lignans（including sesamin and episesamin）and 6 mg astaxanthin daily for 8 weeks. Subjects reported feeling of fatigue and quality of life were examined using the Visual Analogue Scale（VAS）. Results　The per-protocol analysis revealed significant improvements in the VAS scores of the fatigue feeling at 4 weeks in the test food groups compared to the placebo food groups（P＜0.05）, and these scores tended to be lower in the test food groups than the placebo food groups at 8 weeks（P＜0.1）. Conclusions　The results suggested that the intake of combined supplements of sesame lignans（including sesamin and episesamin）and astaxanthin reduced feeling of daily fatigue. （UMIN ID: UMIN000041552）（Jpn Pharmacol Ther 2022；50：1111‒9）