薬理と治療

Abstract

Objective　The study aimed to evaluate the effect of Salacia extract and naringin on blood glucose. Methods　A randomized, double-blind, placebo-controlled, parallel-group study was conducted in 60 healthy volunteers. The subjects were randomly divided into two groups and took placebo food or test food containing Salacia extract and naringin for 12 weeks. The primary outcome was HbA1c and the secondary outcome was fasting blood glucose, insulin, HOMA-IR, 1,5-AG, body weight, BMI and triglycerides. Results　The test food didnʼt suppress HbA1c significantly than placebo, but significantly increased 1,5-AG. Additionally, in the subgroup analysis with higher BMI, the test food significantly suppressed HbA1c than placebo. Conclusion　These results suggest that the ingestion of Salacia extract and naringin suppresses HbA1c in healthy subjects with higher BMI（. UMIN-CTR ID: UMIN000044429）（Jpn Pharmacol Ther 2022；50：1121‒9）