Full text loading...
薬理と治療
Abstract
Objective This study aimed to evaluate the effects of mekabu(sporophyll of Undaria pinnatifida) ingestion in lowering blood pressure and improving swelling. Methods A randomized, single-blind, parallel comparison study was conducted on 60 individuals with high blood pressure(systolic blood pressure[SBP]>160 mmHg and diastolic blood pressure[DBP]>100 mmHg). The participants were divided into two groups, a test food group and a control group. The test food group ingested 35 g of raw mekabu once per day in the morning, noon, or evening, prior to meal intake, for a total of four weeks. SBP, DBP, and pulse rate were measured using an automatic blood pressure monitor, and subjective symptoms of swelling were evaluated by a questionnaire. Salt intake was determined by calculating the 24- hour urinary sodium excretion. Results No significant changes were observed in SBP, DBP, pulse rate, or salt intake before and after the experiment in both groups. In subgroup analysis, a significant reduction in SBP (P<0.05)was observed in the test food group in those with a pre-experimental SBP of <140 mmHg. Subjective symptoms of swelling improved in those with mekabu intake. Conclusion Regular pre-meal intake of mekabu is an effective means of improving swelling, and lowering blood pressure in participants with SBP<140 mmHg. (UMIN-ID: UMIN000046597)(Jpn Pharmacol Ther 2022;50:1613‒22)
Data & Media loading...