薬理と治療

Abstract

Background　Sea buckthorn has been used in medical treatments since ancient time and although the health benefits of this product have been well reported, few studies have disccussed the effect of sea buckthorn on fatigue. Objectives　The aim of this study was to compare a placebo with sea buckthorn juice, which contains significant amount of antioxidant, by assessing its efficacy at combatting fatigue, over 4 weeks period using the Visual Analogue Scale. Methods　We conducted a clinical parallel, double-blind, placebo-controlled trial study to assess the efficacy of sea buckthorn juice on combatting fatigue. 39 healthy women aged 35 to 55 years old were divided by age and body mass index（BMI）at baseline, into the sea buckthorn group, in which the subjects consumed the sea buckthorn juice, and the placebo group, in which the subject consumed placebo. Results　There is a significant difference in changes in the level hunger of pre and post study between the sea buckthorn and placebo groups（P＝0.04）. An decrease in hunger levels was only noted experienced by the participants in the sea buckthorn group（P＜0.05）, whereas these was an increase in hunger level in the placebo group. Conclusions　The study indicated that the intake of sea buckthorn juice decreases hunger through fatigue in the healthy women.（Jpn Pharmacol Ther 2022；50：1639‒44）