薬理と治療

Abstract

Objectives　The purpose of this study is to determine the effect of long-term ingestion of tablets containing hotrienol on stress perception, sleep quality, and sleep state. Methods　A randomized, placebo-controlled, double-blind, crossover study was conducted with 42 healthy adult men and women. Subjects ingested the test table（t a daily dose of 0.12 mg hotrienol）, or the placebo tablet for a period of two weeks. Stress perception, subjective sleep satisfaction and sleep quality were evaluated using the SCL30, OSA and Pittsburg Sleep Questionnaires respectively. Sleep variables identified from quantification of movement during sleep were used to evaluate the sleep state. Results　Analysis of the efficacy of long-term ingestion of hotrienol containing tablets in 33 subjects showed significantly higher scores for OSA Factor Ⅱ: sleep onset and sleep maintenance compared to ingestion of the placebo tablet, and significantly lower overall PSQI scores. The sleep variables; sleep onset latency, bed out latency, and wake after sleep oncet significantly decreased and sleep efficiency significantly improved. Conclusions　Long-term ingestion of tablets containing hotrienol, a compound reported to be effective in relieving chronic stress, has resulted in shortened sleep latency, bed out latency, and awakening time during sleep, leading to improved ease of falling asleep, continuity of good sleep, and ease of rising after waking. Subjective analysis too has shown subjects experienced increased satisfaction with the ease of being able to fall asleep and maintain quality sleep; effects which are thought to contribute to their improved quality of sleep.（UMIN ID: UMIN000044060）（Jpn Pharmacol Ther 2022；50：1709‒16）