薬理と治療

Abstract

Background　Allitol is a rare sugar alcohol obtained by reducing D-allulose and can be found in Itea, a deciduous shrub of the family Saxifragaceae, with D-allulose. Our previous study reported that long-term feeding of rats with dietary dried Itea powder suppressed body fat accumulation. This effect may be due to the simultaneous intake of D-allulose and allitol contained in Itea. Objectives　This study aimed to investigate the effect of the simultaneous intake of allitol and D-allulose on body fat accumulation under fixed feeding in rats. Methods　Thirty-two male Wistar rats（3-week-old）were randomized into four groups of eight rats. The rats were fed with 10 g of control die（t C）, the C diet was supplemented with 0.5 g of D-allulose（P）, 0.5 g of allitol（A）, or 0.5 g of D-allulose and 0.5 g of allitol（PA）for 12 weeks. Results　Final body weight was significantly lower in groups P and PA than in group C. Intra-abdominal adipose tissue weight and carcass fat mass were lower in groups P and PA than that in group C, whereas no significant difference was observed between groups C and A. A synergistic effect of allitol and D-allulose supplementation was observed in the reduction of intra-abdominal adipose tissue weight. Serum and cecal acetic acid levels were found to be significantly higher in groups A and PA than those in groups C and P. Conclusions　Our results suggest that D-allulose inhibits lipogenesis from short-chain fatty acids produced by cecal fermentation of allitol.（Jpn Pharmacol Ther 2022；50：1765‒73）