薬理と治療

Abstract

Objective　The purpose of this study was to evaluate Na absorption inhibitory effect of oral intake of alginates-containing supplements on healthy subjects. Methods　Thirty healthy Japanese males（21-63 years old）were enrolled after background investigation. Each subject was randomized to receive either supplements containing 225 mg alginates or placebo with subsequent crossover of the groups. After adjusting the Na intake by ingesting instructed meals for 3 days, subjects consumed 3 tablets of the assigned test food a day together with instructed meals for 4 days. During the ingestion period, the urinary samples were obtained by 24-hour urine collection. Using the samples, urinary excretion of Na, K, and creatinine were measured. Results　Although this study was conducted as a crossover study, the carry-over effects were observed for urine ⊿ Na levels, which are the primary endpoints, so it was evaluated as a parallel group comparison study using only the data from the first study. In the alginates supplement group, the urine ⊿ Na level showed a significant trend and a significant decrease after 3 days （P＝0.059）and 4 days（P＝0.048）of intake, respectively. No significant differences in ⊿K or ⊿ creatinine levels were observed, except for the ⊿ K level on the first day of intake（P＝0.009）. Conclusions　These results suggest that oral intake of alginates-containing supplements may be effective for suppression of Na absorption. Trial registration　UMIN-CTR UMIN000046641（Jpn Pharmacol Ther 2022；50：1829‒36）