薬理と治療

Abstract

Objective　We examined the effect of ingesting collagen peptide（CP）or CP fermented with Aspergillus sojae（FCP）5.0 g╱day on visceral fat area in healthy participants. Methods　This randomized, double-blind, placebo-controlled study included 55 males and females aged 25-63 years who ingested 5 g of CP, FCP, or placebo（PL）daily for 3 months. Participants were assigned to three groups by stratified random allocation to ensure an even initial visceral fat area. Measurements included visceral fat area, abdominal circumference, and body composition at baseline and 3 months after treatment. Results　No adverse events were identified in any group. Stratification analysis showed that the visceral fat area was significantly reduced in the FCP group with ≥110 cm2 compared with the PL group. A strong correlation was confirmed between the amount of change in visceral fat area and the amount of change in constipation assessment scale score. Conclusion　Our results showed that intake of 5 g of FCP per day for 3 months significantly decreased the visceral fat area in healthy individuals with an initial visceral fat area ≥110 cm2. Ingesting FCP reduces the amount of visceral fat and could potentially contribute to preventing obesity. （UMIN000040736）（Jpn Pharmacol Ther 2022；50：1845‒54）