薬理と治療

Abstract

objective　Lutein and zeaxanthin are pigments present in the macula of the eye that protect the retina from light stimulation. The purpose of this study was to investigate the effects of a test food containing DHA, EPA, and piperine from Piper longumon, in addition to lutein and zeaxanthin, on ocular function in healthy adults. Methods　The study was conducted in a randomized, placebo-controlled, parallel-group trial. Forty participants（25 in each group）received the test or placebo foods containing lutein, zeaxanthin, DHA, EPA, and piperine from Piper longumon for 8 weeks, and performed VDT tasks before, 4 weeks after, and 8 weeks after intake, respectively. Visual acuity for depth and VAS questionnaires were administered before, immediately after, and 20 minutes after the VDT action g was performed. In addition, a questionnaire was administered every week during the intake period. Results　After 8 weeks of intake, visual acuity for depth was significantly improved in the test food group compared to placebo. No adverse events or side effects attributable to the intake of the test foods occurred during the study period. Conclusion　Consumption of foods containing lutein, zeaxanthin, DHA, EPA, and piperine from Piper longumon was shown to improve ocular function in healthy subjects.（UMIN-ID:UMIN000045944）（Jpn Pharmacol Ther 2022；50：1881‒7）