薬理と治療

Abstract

Objectives　This study aims to verify the effects of supplements containing 4′-demethyl nobiletin and 4′-demethyltangeretin on logical thinking ability. Methods　A randomized, double-blind, placebo-controlled, parallel-group comparison study was conducted on subjects who felt their memory decline with aging. Seventy-two Japanese volunteers were randomly assigned to 2 groups and ingested either placebo or the test foods containing 10 mg 4′-demethylnobiletin and 5.2 mg 4′-demethyltangeretin daily for 12 weeks. Subjects were given a logical thinking test to measure their ability to think logically, and their attention, concentration, judgment were examined using cognitive function tests（Cognitrax）. Results　The population from the full analysis set（FAS）revealed significant improvements in the logical thinking test score change amounts at 12 weeks in the test food groups compared to the placebo food groups（P＜0.05）. Additionally, Cognitrax score change amounts at 12 weeks in the test food groups also, significantly showing improvements compared to the placebo food groups（P＜0.05）. Conclusions　The results suggested that the intake of supplements containing 4′-demethyl nobiletin and 4′-demethyltangeretin improved logical thinking ability. （UMIN ID: UMIN000046689）（Jpn Pharmacol Ther 2022；50：2225‒36）