薬理と治療

Abstract

Objective　The study investigated the effects of supplements include composite functional ingredients on obesity. Methods　A randomized, double–blind, placebo–controlled, parallel–group study was conducted. Healthy subjects aged 20 to 65 years with a body mass index of 23 to below 30, and without change in body weight for half a year were selected. They were randomly assigned into three groups, and ingested either supplement A, B or placebo. Result　The abdominal fat area, body weight, BMI and waist circumference were significantly reduced by ingestion of both supplements. Furthermore, both supplement improved gut microbiota. No adverse effects were observed in this study. Conclusion　Supplements containing multiple ingredients indicated anti–obesity effects on healthy overweight subjects whose body weight are difficult to change. （UMIN ID: UMIN000046535）（Jpn Pharmacol Ther 2023；51：209‒21）