薬理と治療

Abstract

Objectives　In this study, we reanalyzed the results of our previously reported paper to see if there were more useful odorant combinations that could test for cognitive decline. Methods　The resulting olfaction scores of 223 subjects were used for reanalysis, with changes in the number of odorant varieties and the allocation of each odorant component, to exploratory analysis of conditions for higher sensitivity and specificity. Results　Six odorants were selected: toothpaste, butter, India ink, apple, soap and Hinoki. When toothpaste was scored 2 points, butter 2 points, and India ink 3 points out of a total of 10 points, the sensitivity was 0.75, 0.85, 0.76, the specificity was 0.69, 0.99, 0.79, the AUC was 0.78, 0.97 and 0.84 for healthy control vs MCI groups, healthy control vs AD groups, and MCI vs AD groups, respectively. Conclusions　The combination of odorants found in this study may discriminate between healthy individuals and those with MCI or AD, thus facilitating early screening for cognitive decline among Japanese patients at high risk of cognitive decline and dementia.（UMIN ID: UMIN000041794）（Jpn Pharmacol Ther 2023；51：225‒33）