薬理と治療

Abstract

Objective　A randomized, double–blind, placebo–controlled, parallel–group study was conducted to determine the effect of food containing tea flower extract standardized for chakasaponin content on human body fat. Methods　Eighty–one disease–free male and female adults with a body mass index（BMI） between 23 and 30 were fed food with 100 mg of tea flower extract, food with 300 mg of tea flower extract, or control food without tea flower extract per day for 12 weeks. The measurements of body fat area（subcutaneous fat area and visceral fat area）by computed tomography scan, BMI, body fat percentage by the impedance method, waist circumference, and blood tests were obtained. Results　Five of 81 patients dropped out of the study because of personal reasons, and 76 patients completed the study. After reviewing the cases, all subjects who completed the study were included in the analysis. After 12 weeks of intake, the total fat area, visceral fat area, and subcutaneous fat area of the 100 and 300 mg tea flower extract groups significantly decreased compared with that of the placebo group. In addition, BMI and waist circumference were significantly reduced in the 100 and 300 mg tea flower extract groups compared with the placebo group. In terms of body fat percentage by the impedance method, the 100 mg tea flower extract group showed a significant decrease compared with the placebo group after 12 weeks of intake, and the 300 mg tea flower extract group showed a significant decrease compared with the placebo group after 8 and 12 weeks of intake. The 300 mg tea flower extract group showed a significant increase in adiponectin levels after 8 and 12 weeks of intake compared with the placebo group. Adiponectin significantly increased in the 100 and 300 mg tea flower extract groups after 12 weeks of intake compared with the placebo group. Conclusion　The results showed that food with tea flower extract was effective in reducing body fat and as a health–promoting food.（UMIN–CTR: UMIN000047267）（Jpn Pharmacol Ther 2023；51：249‒56）