薬理と治療

Abstract

Objectives　Ginger extact contains 6–shogaol, which is suggested to improve bowel movements. This study aimed to examine the effects of a supplement product containing ginger extract powder E on bowel movements. Methods　A randomized, double–blind, placebo–controlled, parallel–group study was conducted in 30 participants. Participants were randomly assigned to receive either the test product containing 100 mg ginger extract powder E or placebo daily for 4 weeks. Assessment items were number of bowel movements, fecal volume, fecal form, fecal odor, refreshing sensation of bowel movements, measurement of fecal water content in stool, and evaluation of Gastrointestinal Symptom Rating Scale（GSRS）and MOS 36–Item Short–Form Health Survey（SF–36）. Results　The number of bowel movements was significantly improved in the test group compered with the placebo group at periodⅥ（22–28 days of ingestion）. Conclusions　The result suggested that ginger extract ingestion improves bowel movement. （UMIN ID: UMIN000048594）（Jpn Pharmacol Ther 2023；51：643‒53）