薬理と治療

Abstract

Methods　A randomized, placebo–controlled, double–blind, parallel–group study was conducted to investigate the usefulness of a food containing the siberian dahurian larch tree（Larix gmelinii（Rupr.）Rupr.）extract, Lavitol®, on cognitive function in healthy Japanese males and females aged 55 to 79 who were aware of memory loss or had been pointed out to be forgetful. 　　Subjects consumed two capsules of the test food（containing taxifolin 48.6 mg/capsule）or the control food daily for 12 weeks. Results　Food containing Lavitol® improved“Motor speed”of Cognitive domain score,“ Correct responses（Immediate memory）”and“Correct responses（Delayed memory）”scores in Visual Memory Test, and“Right taps average”score in Finger Tapping Test at 6 W in Cognitrax. The“Correct responses（Delayed memory）”of Visual Memory Test showed an improvement continuously until 12 W. Furthermore, the Japanese version of POMS2（Profile of Mood States 2nd Edition）showed an improvement in negative mood due to a decrease in T–point of “Total Mood Disturbance（TMD）”at 6 W. In addition, no severe or serious adverse events were observed in this study, and there are no safety issues regarding the continued intake of the test food. Conclusions　Lavitol® intake was effective in improving the ability to recall memorized figures among the cognitive functions of healthy adults who were aware of forget things or who had been pointed out to be forgetful. It may also be effective in improving“Motor speed”and negative mood.（Jpn Pharmacol Ther 2023；51：655‒74）