薬理と治療

Abstract

Objectives　A randomized, double–blind, placebo–controlled, parallel–group study was conducted to evaluate the effect of food containing Garcinia indica extract on liver function in healthy subjects. Methods　This study enrolled 60 healthy subjects with a body mass index＜30. The subjects were randomly divided into two groups, and they consumed either food containing G. indica extract or a placebo for 12 weeks. Liver function was evaluated by measuring serum liver enzyme levels of alanine aminotransferase（ALT）, aspartate aminotransferase（AST）, and γ– glutamyl transpeptidase at baseline and 4, 8, and 12 weeks of ingestion. Results　The G. indica extract group showed a significant reduction in ALT and AST levels（P ＜0.05）compared to the placebo group. No adverse effects of the test food on the subjects were observed during the study period. Conclusions　Overall, the findings indicated that foods containing G. indica extract had a positive effect on liver function in healthy subjects.（UMIN–CTR ID: UMIN000047438）（Jpn Pharmacol Ther 2023；51：703‒9）