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Lactobacillus delbrueckii ssp. bulgaricus OLL1073R—1 で発酵したヨーグルトに含まれる菌体外多糖のナチュラルキラー細胞活性に対する用量依存的作用
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JPY
Abstract
Objectives Lactobacillus delbrueckii ssp. bulgaricus OLL1073R–1 produces the exopolysaccharides(R1–EPS)that have been reported to possess immunomodulatory properties. We previously found that yogurt fermented with L. bulgaricus OLL1073R–1 enhanced natural killer(NK)cell activity. The purpose of this study was to clarify whether R1–EPS in the yogurt enhanced NK cell activity in a dose–dependent manner. Methods Mice were divided into three groups and orally administered yogurt containing 41.7 μg/mL R1–EPS(normal yogurt group), containing 80.8μg/mL R1–EPS(high EPS yogurt group)or distilled water(control group)for 3 weeks. Results NK cell activity was enhanced in the order of control group<normal yogurt group< high EPS yogurt group with statistical differences. In addition, R1–EPS induced IFN–γ production from human peripheral blood mononuclear cells in the presence of concanavalin A in a concentration–dependent manner up to a certain concentration of R1–EPS. Conclusions These results suggest that R1–EPS intake can induce IFN–γ production and enhance NK cell activity in a dose–dependent manner up to a certain amount.(Jpn Pharmacol Ther 2023;51:751‒6)
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