薬理と治療

Abstract

Objectives　This study was conducted to compare changes in blood glucose levels when subjects with impaired glucose tolerance ingested a liquid nutrient containing palatinose and partially hydrolyzed guar gum（PHGG）and a medical enternal nutrient. Methods　In this randomized crossover trial, nineteen patients with glucose intolerance were recruited and assigned to two groups ingesting either test food or control food. Test food is a concentrated liquid which contains palatinose（a sugar that is digested and absorbed slowly）, and PHGG（a dietary fiber）. Control food is one of the common medical enteral nutrient. The blood glucose levels of the subjects were measured every 15 minutes from 0 to 150 minutes after ingestion using a commercially available 24–hour continuous self–monitoring blood glucose meter, isCGM. We analysed the difference of the blood glucose trend and iAUC between the test nutrient and control nutrient. Results　The blood glucose levels after ingestion of the test food were significantly lower at 30, 75, and 90 minutes after ingestion compared to the control food. On the other hand, the blood glucose levels at 120 and 135 minutes were significantly higher in test food group. The iAUC in test food was also significantly lower than the control food. Conclusion　The concentrated liquid nutrient containing palatinose and PHGG（test food）can significantly suppress the increase of blood glucose level compared to the medical enteral nutrient（control food）. Trial registration　UMIN–CTR UMIN000048929（Jpn Pharmacol Ther 2023；51：757‒63）