薬理と治療

Abstract

Objective　The aim of this study was to evaluate the effect of AQUARIUS–ORS（sample）water and electrolytes supplementation in healthy adults with sauna induced dehydration of heatstroke. Methods　A randomized, double–blind, placebo–controlled crossover comparison study was conducted in 15 healthy men subjects. All participants were instructed to remain in a dry sauna for 10 minutes period×3 times. After completing the three periods, subjects were instructed to consume an amount of sample or Mineral Water（placebo）comparable to the amount of water lost through sweating in the sauna as calculated by weight loss over 30 minutes. Body weight, body weight change and rate of body weight change, serum and urinary electrolytes concentrations, hematological parameters, and blood chemistry values were assessed before and after sauna bathing and up to 4 hours after ingestion of the sample or placebo. Results　After sauna bathing, the sample intake group replenished fluids and electrolytes more quickly and maintained than the placebo intake group until the end of the study. Body weight, blood, and electrolytes in urine showed statistically significant improvements in the sample group compared to the placebo group after 2 hours of ingestion. No adverse events related to the study food were identified during the study period. Conclusions　AQUARIUS–ORS, an oral rehydration solution, was confirmed to be more effective for water and electrolytes supplementation in healthy adults with sauna–induced dehydration of heatstroke.（ UMIN ID: UMIN000043913）（Jpn Pharmacol Ther 2023；51：893‒907）