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The effects of melinjo seed extract on uric acid levels―A randomized double—blind placebo—controlled parallel—group study―
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JPY
Abstract
Objectives We designed a clinical study in order to evaluate the effects on uric acid levels and the safety with regard to melinjo seed extract(MSE). Methods This study was a randomized double–blind, placebo–controlled, parallel–group clinical trial. Sixty participants were randomly assigned into three groups, MSE 750 mg/day group, MSE 375 mg/day group and placebo group. Twenty participants in each group took MSE 750 mg/day or MSE 375 mg/day or placebo for 12 weeks. Statistical analyses were performed in order to compare biomarkers between MSE groups and placebo group. Finally, 19 participants in each group completed the trial. Results MSE decreased uric acid levels in participants who had high uric acid levels(5.5–7.0mg/dL)by taking MSE 750 mg/day. There were no safety issues with taking MSE. Conclusions This study revealed that MSE decreases uric acid levels in human with high uric acid levels.(UMIN000040821)(Jpn Pharmacol Ther 2023;51:921‒8)
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