薬理と治療

Abstract

In this study, we investigated the effects of persimmon fruit polyphenols for intoxication attenuation. In an animal test, oral administration of persimmon polyphenols（500 mg/kg）significantly suppressed blood alcohol concentration compared to the Control group（P＜0.01）. In a human trial, the polyphenol group ingesting 200 mg of persimmon polyphenols significantly suppressed the breath alcohol concentration compared to the placebo group（P＜0.05）. With flicker value evaluation, the flicker value was significantly reduced in the polyphenol group compared to that in the placebo group（P＜0.05）, suggesting intoxication attenuation. In addition, the degree of intoxication measured, as determined by using the Uchida–Kraepelin performance test, showed a downward trend（P＝0.06）in the polyphenol group compared to that in the placebo group. Furthermore, regarding subjective symptoms, the polyphenol group showed significant improvement in“tiredness”and“upset stomach”（P＜0.05）, as well as improved “drowsiness”（P＝0.06）.　　Conclusively, we posit that the intake of persimmon polyphenols reduced the degree of intoxication.（Jpn Pharmacol Ther 2023；51：1001‒11）