薬理と治療

Abstract

Objectives　This study was conducted to examine the effects of ingesting yogurt fermented with Lactobacillus delbrueckii subsp. bulgaricus OLL1073R–1 on immune function and physical condition in healthy adults. Methods　This study was a randomized, placebo–controlled, double–blind, parallel–group trial. 110 healthy adults were divided into R–1 and placebo groups, and ingested yogurt fermented with L. bulgaricus OLL1073R–1 or placebo once a day for 4 weeks. The evaluation of immune parameters, health–related quality of life（SF–36v2）and mood profile（POMS2）were conducted before（0 week）, 2 weeks and 4 weeks after the start of ingestion. In addition, subjective symptoms were surveyed from pre–observation period to after 4 weeks of ingestion. Results　The changes in the proportion of CD86 positive cells in plasmacytoid dendritic cells （pDC）and classical dendritic cells（cDC）, respectively, were significantly higher in the R–1 group than the placebo group during the ingestion period. IFN–α and IFN–β production from peripheral blood mononuclear cells tended to be higher in the R–1 group than the placebo group during the ingestion period. The concentration of secretory immunoglobulin A（SIgA）in saliva was significantly higher in the R–1 group than the placebo group after 4 weeks of intake. Based on the subjective symptoms survey, local symptom such as“arthralgia”and systemic symptoms such as“chill”were significantly relieved in the R–1 group than the placebo group after 2–3 weeks, after 3–4 weeks of ingestion, respectively. In addition, SF–36v2 scores for “General health”and POMS2 scores for“Vigor–Activity”were significantly higher in the R–1 group than the placebo group during the ingestion period. Conclusions　Ingestion of yogurt fermented with L. bulgaricus OLL1073R–1 activated both pDC and cDC, which play important roles for innate and acquired immunity, and improved subjective local and systemic symptoms, and health status. In addition, salivary SIgA levels, important in acquired immunity, were increased by ingestion of the yogurt. These results suggest that ingestion of yogurt fermented with L. bulgaricus OLL1073R–1 maintains immune function and physical condition in healthy adults.（UMIN ID: UMIN000045839）（Jpn Pharmacol Ther 2023；51：1297‒309）