薬理と治療

Abstract

Objectives　We aimed to evaluate whether the intake of coriander（Coriandrum sativum L.）leaves, containing 2S,3S–2–O–caffeoyl–hydroxycitric acid, could improve nasal discomfort and quality of life（QOL）during the Japanese cedar pollen season. Methods　We conducted a randomized, double–blind, placebo–controlled trial. We randomly assigned twenty–eight healthy males and females to the dried coriander leaf diet group（2.1 g/ day）or the placebo diet group. We assessed nasal discomfort and QOL using the Japanese Rhino–conjunctivitis Quality of Life Questionnaire（JRQLQ）at baseline and 2, 4, 6, and 8 weeks during the intake period. Results　The dried coriander leaf diet group had a markedly lower nasal discomfort score in comparison with the placebo group at eight weeks after ingestion. In addition, the dried coriander leaf diet group had markedly lower QOL scores in the psycho–life and physical categories compared to the placebo group at six weeks after ingestion. We did not observe any problematic physiological signs or adverse events related to the ingestion of dried coriander leaves on safety analysis. Conclusion　We conclude that continuous intake of dried coriander leaves is an effective approach to alleviate nasal discomfort and QOL during Japanese cedar pollen dispersal（UMIN–CTR ID: 000039247）.（Jpn Pharmacol Ther 2023；51：1329‒39）