薬理と治療

Abstract

Objective　We evaluated the effects of continuous intake of coffee–derived trigonelline on resting energy expenditure in this randomized, double–blind, placebo–controlled, parallel– group comparison study. Methods　100 healthy subjects between 20 and 29 years of age with a BMI 18.5 or over and under 30 were randomly divided into two groups. Subjects received either the test food containing 150 mg of coffee–derived trigonelline or a placebo food（not containing trigonelline） for 8 weeks. Resting energy expenditure was measured at 0（Screening）, 4, and 8 weeks. Results　In the analysis of all subjects, there were no differences in the primary endpoint of resting energy expenditure（27℃, 19℃）and all secondary endpoints in both measured values and changes between the test food and placebo food groups. However, subgroup analyses of resting energy expenditure, respiratory quotient, and brown adipose tissue in subjects with BMI 23 or over and under 30 showed significantly higher resting energy expenditure at 27℃（P＜ 0.05）and tendency of higher brown adipose tissue density（P＜0.10）in the test food intake group at 8 weeks. No adverse events attributable to the test food were observed throughout the study period. Conclusion　In summary, the results suggested that coffee–derived trigonelline for 8 weeks continuously intake improves resting energy expenditure in subjects with higher BMI（23≤ BMI＜30）. However, the number of subjects in the subgroup analyses was limited, therefore further clinical trial is needed. （UMIN ID: UMIN000050139）.（Jpn Pharmacol Ther 2023；51：1713‒29）