薬理と治療

Abstract

Objectives　Mogrol is an aglycone form of mogrosides, a triterpenoid glycoside characteristic of the cucurbitaceous plant Siraitia grosvenorii swingle. In previous studies, since mogrol is known to regulate blood glucose levels in vitro and in vivo via activation of Adenosine monophosphate–activated protein kinase（AMPK）and Transmembrane G protein–coupled receptor 5（TGR5）, we investigated the effect of a single oral dose on postprandial blood glucose levels in humans. Methods　A randomized, placebo–controlled, double–blind, crossover study was conducted in 34 healthy adult volunteers（17 males and 17 females, aged from 24 to 62 years）with fasting glucose levels less than 126 mg/dL. Incremental area under the curve（IAUC）of blood glucose and insulin levels were measured before and 30, 60, 90, and 120 minutes after ingestion of the placebo or test foods and after ingestion of cooked rice. This study protocol was registered prospectively in UMIN–CTR（UMIN000048012）. Results　Consumption of the test food significantly suppressed the rise in postprandial blood glucose levels compared with consumption of the placebo food. The blood glucose IAUC in the test food group（68.2±32.4 mg・h/dL）was significantly lower than in the placebo food group （79.6±46.3 mg・h/dL）（P＜0.05）. The insulin IAUC was not different between the two groups. Conclusions　Mogrol suppressed the increase in postprandial blood glucose levels in humans.（Jpn Pharmacol Ther 2024；52：201‒11）