薬理と治療

Abstract

Objectives　A randomized, double–blind, placebo–controlled, parallel–group study was conducted to evaluate the effect of food containing Garcinia indica extract on mood in healthy participants. Methods　Seventy healthy participants were enrolled and randomly divided into two groups: test food group, consumed test food containing G. indica extract（18 mg/day as garcinol）for 4 weeks, and placebo group, consumed food without G. indica extract（placebo）for 4 weeks. At baseline and after 4 weeks of intake, the Profile of Mood States 2nd Edition（POMS2）and the MOS 36–Item Short–Form Health Survey（SF–36）were used to assess the effects on mood, and the Oguri–Shirakawa–Azumi（OSA）sleep inventory was used to assess the effects on sleep quality. Results　The test food group showed a significant increase in POMS2 scores for“Vigor–Activity”; SF–36 scores for“Vitality,”“Role Emotional,”and“Mental Health”; and OSA sleep inventory scores for“fatigue recovery.”Additionally, a significant reduction in POMS2 scores for“Total Mood Disturbance”and“Fatigue–Inertia”was observed in the test food group compared with those in the placebo group（P＜0.05）. No adverse effects of the test food on the participants were observed during the study period. Conclusions　Overall, the findings indicated that foods containing G. indica extract had positive effects on mood and sleep quality in healthy participants. （UMIN–CTR ID: UMIN000051050）（Jpn Pharmacol Ther 2024；52：213‒20）