薬理と治療

Abstract

Objectives　We conducted a cross–sectional study to examine the relationship between immunological parameters and lifestyles by healthy adults. Methods　Salivary secretory immunoglobulin A（sIgA）concentrations, sIgA secretion rates, Natural Killer（NK）cell activities, and lifestyle questionnaires were examined to 542 subjects in Japanese men and women more than 20 years old. The questionnaire included questions on exercise, diet, and other lifestyle habits, such as drinking and smoking. Results　No correlations were found between salivary sIgA and lifestyles in full analysis set. Salivary sIgA secretion rates were negatively correlated age（Spearman rank correlation coefficient, r＝－0.1063, P＝0.019）in analysis set on excluding outliers. 　　Multiple regression models showed that higher NK cell activity was significantly associated with intake of yogurt（P＝0.010）, and men（P＝0.010）. Conclusions　These results suggest that intake of yogurt helps to improve the decline in immune function associated with aging. （Jpn Pharmacol Ther 2024；52：413‒34）