薬理と治療

Abstract

Objectives　This study aimed to investigate the effects of Lactiplantibacillus plantarum 22A–3 (LP22A–3)on liver function through the modulation of intestinal permeability in healthy individuals. Methods　In this open study, 12 healthy Japanese men and women with higher liver function–related indexes and body mass index of 23-<30.0 kg/m2 were enrolled. The participants consumed the test food containing 40 mg of LP22A–3 daily for 12 weeks. Results　Regulatory T cells and zonulin levels showed significant changes following the intake of LP22A–3. It was observed that LP22A–3 improved intestinal permeability by suppressing inflammation in the lamina propria and maintained intestinal homeostasis. Moreover, no safety issues were observed with the use of LP22A–3 under the study conditions. Conclusion　These findings suggest that LP22A–3 improves intestinal permeability in healthy participants, thereby contributing to the maintenance of intestinal homeostasis. This study was registered with the University Hospital Medical Information Network Clinical Trials Registry.(UMIN ID: UMIN000048757)(Jpn Pharmacol Ther 2024;52:791‒7)