薬理と治療

Abstract

Objectives　The aim of this study was to investigate the effect of consuming Tartary buckwheat ʻManten–Kirariʼon the visceral fat mass and its safety in healthy adults. Methods　A randomized, placebo–controlled, double–blind, parallel–group comparison study was conducted in 60 healthy volunteers(aged 20–60, body mass index(BMI)23 or more and less than 30). Subjects were randomly divided into two groups and consumed either Tartary buckwheat or placebo(Buckwheat)100 mg once per day for 12 weeks. Subjects were assessed on abdominal visceral fat area, physical measurement, and safety assessment. Abdominal visceral fat area was the primary outcome, and physical measurements were the secondary outcomes. Results　Abdominal visceral fat area at 12 weeks was significantly lower in the Tartary buckwheat group than in the placebo food group(P=0.004). During the study period, no adverse events attributable to the test foods were observed. Conclusions　This study suggests that Tartary buckwheaʻt Manten–Kirariʼhave an effect of reducing abdominal visceral fat area in healthy adults and is useful functional food for controlling visceral fat.( UMIN–CTR ID: 000051633)(Jpn Pharmacol Ther 2024;52:1051‒63)