薬理と治療

Abstract

Objective　AQUASOLITA®(AQS)is a beverage intended to replenish water and electrolytes, containing sodium(35 mEq/L), potassium(20 mEq/L), chloride(33 mEq/L), and glucose (1.1%). In this study, the effect of AQS on water and electrolyte replenishment in healthy adult men with sauna–induced dehydration was evaluated. Method　A randomized, crossover trial, using mineral water (MW)as a control, was conducted in 30 healthy men. All participants underwent three 10–minute sauna bathing sessions. After that, participants ingested either AQS or MW in an amount equivalent to their weight loss. Body weight, serum and urinary electrolytes concentrations, hematological parameters, and blood chemistry values were evaluated from before sauna bathing up to 240 minutes after ingestion. Result　Participants exhibited mild dehydration after sauna bathing. After ingesting the test beverages, the AQS group showed significantly better recovery compared to the MW group in serum Na(30, 60, 120 minutes after ingestion), K(30, 60, 120 minutes), Cl(30, 60 minutes), and FENa(60, 120, 180, 240 minutes), despite no significant difference in body weight change. Especially, the estimated mean group difference of FENa, as an indicator of hydration effect, was the largest at 120 minutes(0.42, 95% CI: 0.31–0.53). Moreover, the estimated mean group differences of Na, K, and Cl at the same time were 0.8(95% CI: 0.39–1.20), 0.15(95% CI:0.04–0.25), and 0.37(95% CI: -0.04–0.78), respectively. Conclusion　Although AQUASOLITA®, an oral dehydration solution, was effective for water and electrolyte replenishment in healthy adults with sauna–induced dehydration, there was no significant difference in body weight change.(Jpn Pharmacol Ther 2024;52:1185‒204)